Although postoperative pelvic radiation and/or chemotherapy are often given, they have not been shown conclusively to increase survival. The most commonly used chemotherapeutic drugs include vincristine + doxorubicin or actinomycin-D + cyclophosphamide + DTIC .
Advanced leiomyosarcoma is treated with radiation therapy and/or chemotherapy.
Investigational
• Current studies include comparing postoperative pelvic radiation therapy versus no treatment, and
chemotherapy.
• Cisplatin has been shown not to be of benefit.
• For women with advanced disease, doxorubicin in combination with DTIC or cyclophosphamide has been
shown to be no more effective than doxorubicin alone.
• Vincristine has been used with actinomycin-D or doxorubicin and cyclophosphamide with or without DTIC
with some effectiveness in advanced disease.
• Mitoxantrone , a drug similar to doxorubicin, and ifosfamide are being studied.
